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Hwa-Chain Robert Wang
Professor
Biomedical and Diagnostic Sciences

Clinical Interests

  • Clinical studies for anticancer agents

Research Interests

My research interests are to pursue novel molecules functioning in apoptosis of malignantly transformed cells and to build translational research as a bridge from basic research to clinical research and applications for anticancer therapeutics and prevention. The goal of my basic research is to have a better understanding of the control of human cancers through exploration of novel signaling pathways for regulating cellular transformation, quiescence, and apoptosis. The approach of my translational research is to build preclinical models that reflect the molecular basis of cancer etiology and progression and for studies of tumor biology and etiology. Through molecular classification of oncogene- or carcinogen-induced human cancer cells, the biological, biochemical, genetic, and molecular changes will be utilized as elements to constitute unique, identifiable characteristics of signatures of precancerous and cancerous cells at all stages of cancer development. Based on the biological and molecular signatures of precancerous and cancerous cells, we will be able to determine the stage of cancers and identify molecular targets for choosing agents that prevent cancer by interfering with the biological processes underlying cancer development or selectively induce apoptosis of cancerous cells. Through collaborations we expect to establish research programs with multi-disciplines to link basic molecular and cellular research to clinical studies that will benefit our society for anticancer prevention and treatment.

Education

  • 1990, Ph.D. Molecular Biology/Oncogene, University of Virginia Health Science Center, Charlottesville, Virginia
  • 1984, MS, Veterinary Viral Infectious Diseases, Auburn University, School of Veterinary Medicine, Auburn, Alabama
  • 1979, DVM equivalent (BVM), Veterinary Medicine, National Chung-Hsing University, Taiwan, R.O.C.

Training

  • 1992 Postdoctoral Fellow, Biochemistry and Cellular Biology, Harvard University, Cambridge, MA
  • 1994 Postdoctoral Research Associate, Intracellular Signaling Pathways, Harvard University, Cambridge, MA

Teaching

  • Postdoctoral research fellow training
  • Graduate student training
  • Graduate Course: Mechanisms of Disease
  • Graduate Course: Disorders of the Endocrine System
  • Graduate Course: Cancer Cell Biology
  • Graduate Course: Cellular & Molecular Basis of Disease
  • Graduate Course: Advanced Genetics/Genomics
  • Research Journal Club: Molecular Oncology
  • Undergraduate Course: Cancer Biology

Current Projects

  • Developing a human breast carcinogenesis cellular model with biological and molecular target endpoints for identifying preventive agents.
  • Developing a human urinary bladder cancer cellular model with acquisition of oncogenic Ras activation for identifying therapeutic agents to selectively induce cell death of oncogenic Ras-associated cancer cells.
  • International Multi-Task Cooperative and Exchange Program, Association of American Veterinary Medical Colleges, Global Initiatives in Veterinary Education (GIVE) Program

Professional Societies

  • American Association for the Advancement of Science
  • American Association for Cancer Research
  • Chinese-American Academic and Professional Association in Southeastern United States
  • International Affairs Committee, Association of American Veterinary Medicine Colleges