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Madhu S. Dhar MS, PhD
Research Associate Professor
Equine Regenerative Medicine
Large Animal Clinical Services

Research Interests

  • Animal models of human disease with special relevance to obesity and diabetes
  • Novel targets of Role of glucose transporters and amino phospholipid translocases in insulin resistance
  • Regulation of gene expression in mouse adipocytes in vivo and in vitro
  • Role of G-protein linked potassium channels in breast cancer cells
  • Glucose and Lipid Metabolism in lean and obese horses

Clinical Interests

  • Link basic molecular and cellular research to clinical cases
  • Identify molecular and cellular targets for complex diseases for translational research.
  • Regenerative medicine - adipose tissue as a source of adult stem cells.

Education

  • Ph.D. Chemistry, University of Poona, India
  • M.S. Biochemistry, University of Poona, India
  • B.S. Chemistry, University of Poona, India

Training

  • 1990 Postdoctoral fellow Biochemistry and Cellular Biology, Univ. of Tenn. Knoxville, TN
  • 1992 Postdoctoral fellow Graduate School of Biomedical Sciences, Univ. of Tenn. Knoxville, TN
  • 1998 Research Assistant Professor Oak Ridge National Laboratory, Oak Ridge, TN
  • 2004 Research Assistant Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN
  • 2006 Research Associate Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN

Teaching

  • Undergraduate and Graduate student research training
  • Graduate and postgraduate course: General, organic and biochemistry
  • Graduate course: Introduction to Genome SCI/TECI - Polygenic Mouse Models of Obesity
  • Graduate and postgraduate course: Evaluation of genetic and nutritional control of obesity and glucose homeostasis
  • Graduate course: Advanced Topics in Nutrition. Nutrient-Gene Interactions in Health and Disease
  • Undergraduate and graduate course: Plant genetic engineering : DNA cloning and sequencing

Professional Societies

  • To establish in vitro and in vivo systems to study the biology of novel targets for obesity and diabetes
  • To validate novel candidate genes in mice, humans and companion animals for their roles in obesity and diabetes
  • To establish siRNAs as therapeutic drugs against clinically important diseases.
  • To optimize the isolation and identification of stem cells from equine peripheral blood and adipose tissue.

Professional Societies

  • International Mammalian Genome Society
  • North American Association for the Study of Obesity
  • Tennessee Mouse Genome Consortium