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Madhu S. Dhar MS, PhD
Research Associate Professor
Equine Regenerative Medicine
Large Animal Clinical Sciences

Research Interests

  • Animal models of human disease with special relevance to obesity and diabetes
  • Novel targets of Role of glucose transporters and amino phospholipid translocases in insulin resistance
  • Regulation of gene expression in mouse adipocytes in vivo and in vitro
  • Role of G-protein linked potassium channels in breast cancer cells
  • Glucose and Lipid Metabolism in lean and obese horses

Clinical Interests

  • Link basic molecular and cellular research to clinical cases
  • Identify molecular and cellular targets for complex diseases for translational research.
  • Regenerative medicine - adipose tissue as a source of adult stem cells.

Madhu Dhar, MS, PhD. Dr. Dhar holds a B.S. (University of Pune, India), a MS (University of Pune, India), and PhD (Chemistry (Major), Biochemistry (Minor) from University of Pune). Dr. Dhar mentors graduate students working toward earning MS and PhD degrees at the University of Tennessee at Knoxzville. Dr. Dhar is the Director of the Tissue Regeneration Laboratory in the Department of Large Animal Clinical Sciences and has a clinical focus in use of cell-based therapies for treatment of disease. Her research focus is in regenerative medicine, animal models of diseases, diabetes and obesity. Her teaching focus includes cell biology, genomics, regenerative medicine, and animal models of diseases. Dr. Dhar provides CE seminars on topics of interest including cell biology, genomics, regenerative medicine, and animal models of diseases.

Education

  • Ph.D. Chemistry, University of Poona, India
  • M.S. Biochemistry, University of Poona, India
  • B.S. Chemistry, University of Poona, India

Training

  • 1990 Postdoctoral fellow Biochemistry and Cellular Biology, Univ. of Tenn. Knoxville, TN
  • 1992 Postdoctoral fellow Graduate School of Biomedical Sciences, Univ. of Tenn. Knoxville, TN
  • 1998 Research Assistant Professor Oak Ridge National Laboratory, Oak Ridge, TN
  • 2004 Research Assistant Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN
  • 2006 Research Associate Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN

Teaching

  • Undergraduate and Graduate student research training
  • Graduate and postgraduate course: General, organic and biochemistry
  • Graduate course: Introduction to Genome SCI/TECI - Polygenic Mouse Models of Obesity
  • Graduate and postgraduate course: Evaluation of genetic and nutritional control of obesity and glucose homeostasis
  • Graduate course: Advanced Topics in Nutrition. Nutrient-Gene Interactions in Health and Disease
  • Undergraduate and graduate course: Plant genetic engineering : DNA cloning and sequencing

Professional Societies

  • To establish in vitro and in vivo systems to study the biology of novel targets for obesity and diabetes
  • To validate novel candidate genes in mice, humans and companion animals for their roles in obesity and diabetes
  • To establish siRNAs as therapeutic drugs against clinically important diseases.
  • To optimize the isolation and identification of stem cells from equine peripheral blood and adipose tissue.

Professional Societies

  • International Mammalian Genome Society
  • North American Association for the Study of Obesity
  • Tennessee Mouse Genome Consortium