{"id":86,"date":"2024-07-18T15:04:32","date_gmt":"2024-07-18T19:04:32","guid":{"rendered":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/?page_id=86"},"modified":"2026-07-08T16:29:51","modified_gmt":"2026-07-08T20:29:51","slug":"research","status":"publish","type":"page","link":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\" style=\"border-style:none;border-width:0px;padding-top:0;padding-bottom:0\">Our laboratory is involved in research activities addressing infectious diseases affecting animals and humans. Our primary focus is on the zoonotic spirochete pathogen <em>Leptospira<\/em>. We use a system approach encompassing multiple aspects of this pathogen, including epidemiology, pathogenesis,&nbsp;diagnostics, and vaccine development.&nbsp; &nbsp;We collaborate with a team of enthusiastic researchers who share their knowledge and expertise to address the current gaps in this field. Our other projects include vaccine and diagnostic development for Canine pathogens, <em>Ehrlichia canis<\/em> <em>and Anaplasma platys<\/em>. We are committed to utilizing all available resources in our quest to make scientific discoveries that can protect not just one but all species.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Areas of Research<\/h2>\n\n\n<style>.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}.kb-row-layout-id86_61cffb-ec > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id86_61cffb-ec > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id86_61cffb-ec alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-4-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column86_958e44-55 > .kt-inside-inner-col,.kadence-column86_958e44-55 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column86_958e44-55 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column86_958e44-55 > .kt-inside-inner-col{flex-direction:column;}.kadence-column86_958e44-55 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column86_958e44-55 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column86_958e44-55{position:relative;}@media all and (max-width: 1024px){.kadence-column86_958e44-55 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column86_958e44-55 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column86_958e44-55\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box86_68a4ec-3d .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box86_68a4ec-3d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;background:#ffffff;padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kt-info-box86_68a4ec-3d .kadence-info-box-icon-container .kt-info-svg-icon, .kt-info-box86_68a4ec-3d .kt-info-svg-icon-flip, .kt-info-box86_68a4ec-3d .kt-blocks-info-box-number{font-size:50px;}.kt-info-box86_68a4ec-3d .kt-blocks-info-box-media{background:var(--global-palette7, #eeeeee);border-color:var(--global-palette7, #eeeeee);border-radius:200px;overflow:hidden;border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.kt-info-box86_68a4ec-3d .kt-blocks-info-box-media-container{margin-top:0px;margin-right:15px;margin-bottom:10px;margin-left:15px;}.kt-info-box86_68a4ec-3d .kt-infobox-textcontent h2.kt-blocks-info-box-title{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:5px;margin-right:0px;margin-bottom:10px;margin-left:0px;}.kt-info-box86_68a4ec-3d .kt-blocks-info-box-learnmore{background:transparent;border-width:0px 0px 0px 0px;padding-top:4px;padding-right:8px;padding-bottom:4px;padding-left:8px;margin-top:10px;margin-right:0px;margin-bottom:10px;margin-left:0px;}@media all and (max-width: 1024px){.kt-info-box86_68a4ec-3d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}@media all and (max-width: 767px){.kt-info-box86_68a4ec-3d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}<\/style>\n<div class=\"wp-block-kadence-infobox kt-info-box86_68a4ec-3d\"><span class=\"kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-center\"><div class=\"kt-infobox-textcontent\"><h2 class=\"kt-blocks-info-box-title\">Pathogens<\/h2><p class=\"kt-blocks-info-box-text\"><em>Leptospira<\/em><br><em>Anaplasma<\/em><br><em>Ehrlichia<\/em><\/p><\/div><\/span><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column86_06cd39-0c > .kt-inside-inner-col,.kadence-column86_06cd39-0c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column86_06cd39-0c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column86_06cd39-0c > .kt-inside-inner-col{flex-direction:column;}.kadence-column86_06cd39-0c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column86_06cd39-0c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column86_06cd39-0c{position:relative;}@media all and (max-width: 1024px){.kadence-column86_06cd39-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column86_06cd39-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column86_06cd39-0c\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box86_c69966-6d .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box86_c69966-6d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;background:#ffffff;padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kt-info-box86_c69966-6d .kadence-info-box-icon-container .kt-info-svg-icon, .kt-info-box86_c69966-6d .kt-info-svg-icon-flip, .kt-info-box86_c69966-6d .kt-blocks-info-box-number{font-size:50px;}.kt-info-box86_c69966-6d .kt-blocks-info-box-media{border-color:var(--global-palette7, #eeeeee);border-radius:200px;overflow:hidden;border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:0px;margin-right:20px;margin-bottom:0px;margin-left:0px;}.kt-info-box86_c69966-6d .kt-infobox-textcontent h2.kt-blocks-info-box-title{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:5px;margin-right:0px;margin-bottom:10px;margin-left:0px;}.kt-info-box86_c69966-6d .kt-blocks-info-box-learnmore{background:transparent;border-width:0px 0px 0px 0px;padding-top:4px;padding-right:8px;padding-bottom:4px;padding-left:8px;margin-top:10px;margin-right:0px;margin-bottom:10px;margin-left:0px;}@media all and (max-width: 1024px){.kt-info-box86_c69966-6d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}@media all and (max-width: 767px){.kt-info-box86_c69966-6d .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}<\/style>\n<div class=\"wp-block-kadence-infobox kt-info-box86_c69966-6d\"><span class=\"kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-left kt-info-halign-center\"><div class=\"kt-infobox-textcontent\"><h2 class=\"kt-blocks-info-box-title\">Epidemiology<\/h2><p class=\"kt-blocks-info-box-text\">Based on the \u201cOne Health\u201d significance and growing emergence due to climate change, we continue to estimate the prevalence and impact of <em>Leptospira<\/em> in animal population and environment.<\/p><\/div><\/span><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column86_c37c56-a5 > .kt-inside-inner-col,.kadence-column86_c37c56-a5 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column86_c37c56-a5 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column86_c37c56-a5 > .kt-inside-inner-col{flex-direction:column;}.kadence-column86_c37c56-a5 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column86_c37c56-a5 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column86_c37c56-a5{position:relative;}@media all and (max-width: 1024px){.kadence-column86_c37c56-a5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column86_c37c56-a5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column86_c37c56-a5\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box86_cb96d6-64 .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box86_cb96d6-64 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;background:#ffffff;padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kt-info-box86_cb96d6-64 .kadence-info-box-icon-container .kt-info-svg-icon, .kt-info-box86_cb96d6-64 .kt-info-svg-icon-flip, .kt-info-box86_cb96d6-64 .kt-blocks-info-box-number{font-size:50px;}.kt-info-box86_cb96d6-64 .kt-blocks-info-box-media{background:var(--global-palette7, #eeeeee);border-radius:200px;overflow:hidden;border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;}.kt-info-box86_cb96d6-64 .kt-blocks-info-box-media-container{margin-top:0px;margin-right:15px;margin-bottom:10px;margin-left:15px;}.kt-info-box86_cb96d6-64 .kt-blocks-info-box-media .kadence-info-box-image-intrisic img{border-radius:200px;}.kt-info-box86_cb96d6-64 .kt-infobox-textcontent h2.kt-blocks-info-box-title{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:5px;margin-right:0px;margin-bottom:10px;margin-left:0px;}.kt-info-box86_cb96d6-64 .kt-blocks-info-box-learnmore{background:transparent;border-width:0px 0px 0px 0px;padding-top:4px;padding-right:8px;padding-bottom:4px;padding-left:8px;margin-top:10px;margin-right:0px;margin-bottom:10px;margin-left:0px;}@media all and (max-width: 1024px){.kt-info-box86_cb96d6-64 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}@media all and (max-width: 767px){.kt-info-box86_cb96d6-64 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}<\/style>\n<div class=\"wp-block-kadence-infobox kt-info-box86_cb96d6-64\"><span class=\"kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-center\"><div class=\"kt-infobox-textcontent\"><h2 class=\"kt-blocks-info-box-title\">Diagnostics<\/h2><p class=\"kt-blocks-info-box-text\">We offer Leptospira diagnostic services to the veterinary community. We are also engaged in improving current diagnostic methodology and developing universal diagnostic tests.<\/p><\/div><\/span><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column86_1448fd-3e > .kt-inside-inner-col,.kadence-column86_1448fd-3e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column86_1448fd-3e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column86_1448fd-3e > .kt-inside-inner-col{flex-direction:column;}.kadence-column86_1448fd-3e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column86_1448fd-3e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column86_1448fd-3e{position:relative;}@media all and (max-width: 1024px){.kadence-column86_1448fd-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column86_1448fd-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column86_1448fd-3e\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box86_60a127-26 .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box86_60a127-26 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;background:#ffffff;padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kt-info-box86_60a127-26 .kadence-info-box-icon-container .kt-info-svg-icon, .kt-info-box86_60a127-26 .kt-info-svg-icon-flip, .kt-info-box86_60a127-26 .kt-blocks-info-box-number{font-size:50px;}.kt-info-box86_60a127-26 .kt-blocks-info-box-media{background:var(--global-palette7, #eeeeee);border-radius:200px;overflow:hidden;border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;}.kt-info-box86_60a127-26 .kt-blocks-info-box-media-container{margin-top:0px;margin-right:15px;margin-bottom:10px;margin-left:15px;}.kt-info-box86_60a127-26 .kt-blocks-info-box-media .kadence-info-box-image-intrisic img{border-radius:200px;}.kt-info-box86_60a127-26 .kt-infobox-textcontent h2.kt-blocks-info-box-title{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:5px;margin-right:0px;margin-bottom:10px;margin-left:0px;}.kt-info-box86_60a127-26 .kt-blocks-info-box-learnmore{background:transparent;border-width:0px 0px 0px 0px;padding-top:4px;padding-right:8px;padding-bottom:4px;padding-left:8px;margin-top:10px;margin-right:0px;margin-bottom:10px;margin-left:0px;}@media all and (max-width: 1024px){.kt-info-box86_60a127-26 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}@media all and (max-width: 767px){.kt-info-box86_60a127-26 .kt-blocks-info-box-link-wrap{border-top:5px solid #f2f2f2;border-right:5px solid #f2f2f2;border-bottom:5px solid #f2f2f2;border-left:5px solid #f2f2f2;}}<\/style>\n<div class=\"wp-block-kadence-infobox kt-info-box86_60a127-26\"><span class=\"kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-center\"><div class=\"kt-infobox-textcontent\"><h2 class=\"kt-blocks-info-box-title\">Vaccinology<\/h2><p class=\"kt-blocks-info-box-text\">We invest in antigen discovery and development of improved <em>Leptospira <\/em>vaccines that can be used regardless of host species and infecting strains. We are also working on antigen discovery, vaccine, and diagnostic development for <em>Ehrlichia<\/em> and <em>Anaplasma<\/em> infections in dogs.<\/p><\/div><\/span><\/div>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<h2 class=\"wp-block-heading\">Recent Publications<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sreekumari Rajeev, Jaclyn Azelby, Porsha Reed, Rebekah Jones, Rajeev V. Nair, Brian Johnson. Species Identification and Antimicrobial Susceptibility of Mycobacterial Isolates from Dogs and Cats. <em>Microbiology Society<\/em>, 2026-03-27 | preprint. DOI: <a href=\"https:\/\/doi.org\/10.1099\/acmi.0.001188.v2\" target=\"_blank\" rel=\"noreferrer noopener\">10.1099\/acmi.0.001188.v2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alejandro Llanes, Swetha Madesh, Kalvis Brungulis, Sreekumari Rajeev. High-throughput identification of immunoreactive peptides and corresponding proteins from <em>Anaplasma platys<\/em> and <em>Ehrlichia canis <\/em>using peptide microarray chips. <em>Frontiers in Cellular and Infection Microbiology<\/em>, 2026-01-06 | journal-article. DOI: <a href=\"https:\/\/doi.org\/10.3389\/fcimb.2025.1671309\" target=\"_blank\" rel=\"noreferrer noopener\">10.3389\/fcimb.2025.1671309<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eliza Baker, Michelle M. Dennis, Debra Miller, Sreekumari Rajeev, Mohamed A. Abouelkhair, Alex Jansen, Carmen Black, Richard Gerhold. Survey of Coyotes (<em>Canis latrans<\/em>) for Vector-Borne and Bacterial pathogens in South Carolina and Tennessee, USA. <em>Journal of Wildlife Diseases, <\/em>2025-11-07 | journal-article. DOI: <a href=\"https:\/\/doi.org\/10.7589\/JWD-D-24-00206\" target=\"_blank\" rel=\"noreferrer noopener\">10.7589\/JWD-D-24-00206<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Myranda Gorman, Bryanna Fayne,<strong> <\/strong>Sreekumari Rajeev. Diagnosis of leptospirosis in animals: challenges and perspectives. <em>Journal of Clinical Microbiology,<\/em> 2025-10-30 | mini-review. DOI: <a href=\"https:\/\/doi.org\/10.1128\/jcm.01700-24\" target=\"_blank\" rel=\"noreferrer noopener\">10.1128\/jcm.01700-24<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kellie A. McCreight, Liana N. Barbosa, Odoi Agricola, Porsha Reed, Sreekumari Rajeev. Leptospira seroprevalence in dogs, cats and horses: the effect of cross-reactivity between serovars and vaccination status on seroprevalence estimates. 2024-04-20 | preprint. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2024.04.17.589957\" target=\"_blank\" rel=\"noreferrer noopener\">10.1101\/2024.04.17.589957<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Liana Nunes Barbosa, Alejandro Llanes, Swetha Madesh, Bryanna Fayne, Kalvis Brangulis, Sarah C. Linn-Peirano, Sreekumari Rajeev. Enhancement of clinical signs in C3H\/HeJ mice vaccinated with a highly immunogenic Leptospiramethyl-accepting chemotaxis protein following challenge. 2024-04-18 | preprint. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2024.04.17.590016\" target=\"_blank\" rel=\"noreferrer noopener\">10.1101\/2024.04.17.590016<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ruijie Xu, Dhani Prakoso, Liliana C.M. Salvador, Sreekumari, Rajeev. Leptospira transcriptome sequencing using long-read technology reveals unannotated transcripts and potential polyadenylation of RNA molecules. <em>Microbiology Spectrum<\/em>, 2023-12-12 | journal-article. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1128\/spectrum.02234-23\" target=\"_blank\" rel=\"noreferrer noopener\">10.1128\/spectrum.02234-23<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ruijie Xu, Sreekumari Rajeev, Liliana C.M. Salvador. The selection of software and database for metagenomics sequence analysis impacts the outcome of microbial profiling and pathogen detection. <em>PLOS ONE<\/em>, 2023-04-07\u00a0|\u00a0journal-article. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0284031\" target=\"_blank\" rel=\"noreferrer noopener\">10.1371\/journal.pone.0284031<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Myranda Gorman, Ruijie Xu, Dhani Prakoso, Liliana C.M. Salvadore, Sreekumari Rajeev. Leptospira enrichment culture followed by ONT metagenomic sequencing allows better detection of Leptospira presence and diversity in water and soil samples. <em>PLOS Neglected Tropical Diseases<\/em>, 2022-10-26\u00a0|\u00a0journal-article. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1371\/journal.pntd.0010589\" target=\"_blank\" rel=\"noreferrer noopener\">10.1371\/journal.pntd.0010589<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dhani Prakoso, Xiaojuan Zhu, Sreekumari Rajeev. Galleria mellonella infection model to evaluate pathogenic and nonpathogenic Leptospira strains. <em>Veterinary Microbiology<\/em>, 2022-01\u00a0|\u00a0journal-article. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.vetmic.2021.109295\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.vetmic.2021.109295<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our laboratory is involved in research activities addressing infectious diseases affecting animals and humans. Our primary focus is on the zoonotic spirochete pathogen Leptospira. We use a system approach encompassing\u2026<\/p>\n","protected":false},"author":1238,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","footnotes":""},"class_list":["post-86","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/pages\/86","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/users\/1238"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/comments?post=86"}],"version-history":[{"count":0,"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/pages\/86\/revisions"}],"wp:attachment":[{"href":"https:\/\/vetmed.tennessee.edu\/Leptospira-Research-Diagnostic\/wp-json\/wp\/v2\/media?parent=86"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}