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Barry Rouse

Distinguished Professor | Biomedical and Diagnostic Sciences
Overview

My research is in the field of infectious disease and has focused on viral immunology and immunopathology. We have mainly studied herpes simplex virus (HSV) infection in mice both with a view to devising successful vaccines and more particularly to determine how HSV causes tissue damage in critical tissues such as the eye and nervous system. We have worked on both host innate and adaptive immune mechanisms, particularly the T cells responsible for immunity as well as those involved in orchestrating tissue damage. We have defined the role of several subtypes of proinflammatory T cells as well as numerous cytokines and chemokines. Our group was the first to show a role of regulatory T cells (Treg) in the host response to a virus infection. We demonstrated that Treg responses could act to inhibit the efficiency of immunity, but that Treg were valuable to modulate the severity of immunopathological responses, such as those that occur in the corneal stroma after HSV infection of the eye.

Teaching Focus

Immunology

The College of Veterinary Medicine
University of Tennessee
2407 River Drive
Knoxville, TN 37996
Education and Training
  • D.Sc. - University of Bristol, England - 1997
  • Postdoctoral research - Walter and Eliza Hall Institute of Medical Research, Australia (1970-72)
  • PhD - University of Guelph, Canada - 1970
  • M.Sc. - University of Guelph, Canada -1967
  • University of Bristol, England -1965 - Bachelor of Veterinary Science with honors

Barry Rouse

Distinguished Professor | Biomedical and Diagnostic Sciences
The College of Veterinary Medicine
University of Tennessee
2407 River Drive
Knoxville, TN 37996
Education and Training
  • D.Sc. - University of Bristol, England - 1997
  • Postdoctoral research - Walter and Eliza Hall Institute of Medical Research, Australia (1970-72)
  • PhD - University of Guelph, Canada - 1970
  • M.Sc. - University of Guelph, Canada -1967
  • University of Bristol, England -1965 - Bachelor of Veterinary Science with honors
Overview

My research is in the field of infectious disease and has focused on viral immunology and immunopathology. We have mainly studied herpes simplex virus (HSV) infection in mice both with a view to devising successful vaccines and more particularly to determine how HSV causes tissue damage in critical tissues such as the eye and nervous system. We have worked on both host innate and adaptive immune mechanisms, particularly the T cells responsible for immunity as well as those involved in orchestrating tissue damage. We have defined the role of several subtypes of proinflammatory T cells as well as numerous cytokines and chemokines. Our group was the first to show a role of regulatory T cells (Treg) in the host response to a virus infection. We demonstrated that Treg responses could act to inhibit the efficiency of immunity, but that Treg were valuable to modulate the severity of immunopathological responses, such as those that occur in the corneal stroma after HSV infection of the eye.

Teaching Focus

Immunology